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In-situ hybridisation with a biotinylated cytomegalovirus(CMV)DNA probe was done on brain biopsy specimens from 10 patients with Rasmussen's encephalitis(RE)and 46 age-matched control patients with other neurological diseases.All 10 patients with RE had intractable epilepsy and focal neurological deficits,and there was perivascular cuffing,microglial nodules,astrogliosis,and neuronal loss.CMV genomic material was demonstrated in 7 of the 10 patients with RE(in neurons,astrocytes, oligodendrocytes,and endothelial cells)and in 2 of the 46 control patients.Probes for herpes simplex virus and hepatitis B virus were negative in all patients and in fibroblast controls.The results suggest that CMV is a likely cause of Rasmussen's encephalitis. |
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brain biopsy
cytomegalovirus infection
DNA probes
encephalitis
encephalitis,focal
encephalitis,Rasmussen's
encephalitis,viral
hemiparesis
neuropathology
seizure
seizure,focal
seizure,intractable,treatment of
viral infection
viral infection,CNS
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